STRC

Across TCGA patient cohorts, STRC mutation is significantly associated with the RNA expression of many other genes, with 2,534 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRC-associated genes across cancer lineages are MIR5189, ARRDC3-AS1, and RNU6-532P. Each is linked with STRC in more than 1 cancer types. Because this analysis shows association rather than direction, both STRC-to-partner and partner-to-STRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5189 grouped by STRC-low versus STRC-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRC→partner) and Y-score (partner→STRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MIR5189 →	+0.354	+5.588	<.001	.004	3	2
SKCM	ARRDC3-AS1 →	+0.312	+2.743	<.001	<.001	3	2
BRCA	RNU6-532P →	+0.258	+8.471	<.001	.005	3	2
UCEC	INCENP →	+0.778	+2.949	.001	<.001	3	2
UCEC	CPSF7 →	+0.456	+3.491	.001	.002	3	2
UCEC	TMCO3 →	+0.636	+3.201	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,534 associations by consensus.

MIR5189 by STRC expression — BLCA

Explore this box plot interactively →