STRC

Across TCGA cell cohorts, STRC mutation is significantly associated with the drug of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STRC-associated genes across cancer lineages are AGI-6780, 50869, and Quizartinib. Each is linked with STRC in more than 1 cancer types. Because this analysis shows association rather than direction, both STRC-to-partner and partner-to-STRC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGI-6780 grouped by STRC-low versus STRC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRC→partner) and Y-score (partner→STRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AGI-6780 →	+0.437	+2.868	.016	.022	3	1
LARGE_INTESTINE	50869 →	+0.534	+2.900	.006	.015	3	1
LARGE_INTESTINE	Quizartinib →	+0.442	+2.874	.003	.021	3	1
LARGE_INTESTINE	CX-5461 →	+0.691	+2.874	.012	.021	3	1
LARGE_INTESTINE	PD0325901 →	-0.650	-2.745	.009	.047	2	1
LARGE_INTESTINE	SCH772984 →	-0.566	-2.745	.028	.047	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

AGI-6780 by STRC expression — LARGE_INTESTINE

Explore this box plot interactively →