STRBP

Across TCGA patient cohorts, STRBP mutation is significantly associated with the RNA expression of many other genes, with 2,886 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRBP-associated genes across cancer lineages are HIRIP3, MRPL39, and CCNB2. Each is linked with STRBP in more than 1 cancer types. Because this analysis shows association rather than direction, both STRBP-to-partner and partner-to-STRBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HIRIP3 grouped by STRBP-low versus STRBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRBP→partner) and Y-score (partner→STRBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HIRIP3 →	+0.331	+1.765	.006	<.001	3	2
UCEC	MRPL39 →	+0.342	+2.222	.002	.001	3	2
UCEC	CCNB2 →	+0.574	+2.416	.001	<.001	3	2
UCEC	MIS18A →	+0.461	+2.108	.002	.002	3	2
UCEC	CDC25A →	+0.566	+1.999	<.001	<.001	3	2
UCEC	POC1A →	+0.423	+3.000	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,886 associations by consensus.

HIRIP3 by STRBP expression — UCEC

Explore this box plot interactively →