STRBP

Across TCGA cell cohorts, STRBP mutation is significantly associated with the drug of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STRBP-associated genes across cancer lineages are Leflunomide, 50869, and Venetoclax. Each is linked with STRBP in more than 1 cancer types. Because this analysis shows association rather than direction, both STRBP-to-partner and partner-to-STRBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Leflunomide grouped by STRBP-low versus STRBP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRBP→partner) and Y-score (partner→STRBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Leflunomide →	+0.329	+2.991	.005	.018	3	1
LARGE_INTESTINE	50869 →	+0.481	+2.900	.015	.015	3	1
LARGE_INTESTINE	Venetoclax →	+0.362	+2.777	.025	.038	3	1
LARGE_INTESTINE	TAK-715 →	+0.525	+2.722	.007	.023	3	1
LARGE_INTESTINE	Quizartinib →	+0.416	+2.874	.005	.021	3	1
LARGE_INTESTINE	ARRY-520 →	+0.719	+2.807	.042	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Leflunomide by STRBP expression — LARGE_INTESTINE

Explore this box plot interactively →