STRADA

Across TCGA pan-cancer cohorts, STRADA Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated STRADA data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher STRADA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STRADA expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

OV, ACC, and COAD are the cancer types where STRADA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.028	0.844	<.001	48	view →
ACC	DFS	Median	All	0.046	0.753	<.001	30	view →
COAD	OS	Median	III,IV	0.157	0.791	.001	24	view →
BRCA	OS	Median	III,IV	0.027	0.907	<.001	14	view →
BLCA	DFS	Median	All	1.000	0.325	.022	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

STRADA–OV (OS)

Open the OV breakdown →