STRADA

Across TCGA patient cohorts, STRADA mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRADA-associated genes across cancer lineages are A-Raf_pS299, PCNA, and ATM. Each is linked with STRADA in more than 1 cancer types. Because this analysis shows association rather than direction, both STRADA-to-partner and partner-to-STRADA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by STRADA-low versus STRADA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRADA→partner) and Y-score (partner→STRADA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.196	-3.584	<.001	.002	3	2
UCEC	PCNA →	+0.233	+1.700	.004	.040	3	2
UCEC	ATM →	-0.607	-2.087	<.001	.005	3	2
UCEC	4E-BP1 →	+0.309	+2.614	.002	.005	3	2
UCEC	EGFR_pY1068 →	-0.258	-3.321	.007	.009	3	1
UCEC	ERK2 →	+0.237	+2.115	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

A-Raf_pS299 by STRADA expression — UCEC

Explore this box plot interactively →