STRADA

Across TCGA cell cohorts, STRADA mutation is significantly associated with the drug of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STRADA-associated genes across cancer lineages are AZ20, I-BET-151, and (5Z)-7-Oxozeaenol. Each is linked with STRADA in more than 1 cancer types. Because this analysis shows association rather than direction, both STRADA-to-partner and partner-to-STRADA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZ20 grouped by STRADA-low versus STRADA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRADA→partner) and Y-score (partner→STRADA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZ20 →	+0.466	+2.716	.017	.042	3	1
LARGE_INTESTINE	I-BET-151 →	+0.464	+2.777	.030	.038	3	1
LARGE_INTESTINE	(5Z)-7-Oxozeaenol →	+0.653	+2.649	.016	.046	3	1
LARGE_INTESTINE	RAF_9304 →	+0.477	+2.649	.042	.046	3	1
LARGE_INTESTINE	Leflunomide →	+0.335	+2.678	.008	.037	3	1
LARGE_INTESTINE	Schweinfurthin A →	+0.670	+2.649	.010	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

AZ20 by STRADA expression — LARGE_INTESTINE

Explore this box plot interactively →