STRA6

Across TCGA patient cohorts, STRA6 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRA6-associated genes across cancer lineages are EGFR_pY1068, IGFBP2, and MEK1. Each is linked with STRA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both STRA6-to-partner and partner-to-STRA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by STRA6-low versus STRA6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRA6→partner) and Y-score (partner→STRA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.208	-1.440	.016	.024	3	2
UCEC	IGFBP2 →	-0.569	-1.440	.011	.024	3	2
UCEC	MEK1 →	+0.338	+1.736	.007	.007	3	2
UCEC	Notch1 →	+0.177	+2.920	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.402	+2.070	<.001	.001	3	2
UCEC	Annexin-1 →	+0.672	+2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by STRA6 expression — UCEC

Explore this box plot interactively →