STOX2

Across TCGA patient cohorts, STOX2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STOX2-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and A-Raf_pS299. Each is linked with STOX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both STOX2-to-partner and partner-to-STOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by STOX2-low versus STOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STOX2→partner) and Y-score (partner→STOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.183	+1.536	.003	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.424	+1.267	.012	.026	3	3
UCEC	A-Raf_pS299 →	-0.072	-1.362	.035	.034	3	2
UCEC	ERK2 →	+0.123	+1.152	.026	.048	3	2
UCEC	beta-Catenin →	+0.454	+3.087	.001	<.001	3	2
COAD	c-Jun_pS73 →	-0.137	-2.416	.047	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PCNA by STOX2 expression — UCEC

Explore this box plot interactively →