STOX2

Across TCGA cell cohorts, STOX2 mutation is significantly associated with the RNA expression of many other genes, with 234 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STOX2-associated genes across cancer lineages are EML5, CST5, and OR8B8. Each is linked with STOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STOX2-to-partner and partner-to-STOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EML5 grouped by STOX2-low versus STOX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STOX2→partner) and Y-score (partner→STOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EML5 →	+0.819	+3.364	.005	.002	3	2
CNS	CST5 →	+0.134	+4.981	<.001	.008	3	1
CNS	OR8B8 →	+0.129	+5.321	<.001	.005	3	1
CNS	KRTAP19-7 →	+0.070	+5.754	<.001	.002	3	1
CNS	FAM240B →	+0.091	+4.981	<.001	.008	3	1
BLOOD_Leukemia	RBPJL →	+0.250	+3.418	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 234 associations by consensus.

EML5 by STOX2 expression — LARGE_INTESTINE

Explore this box plot interactively →