STOX1

Across TCGA cell cohorts, STOX1 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STOX1-associated genes across cancer lineages are SLC17A2, ACTL7A, and HSF5. Each is linked with STOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STOX1-to-partner and partner-to-STOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC17A2 grouped by STOX1-low versus STOX1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STOX1→partner) and Y-score (partner→STOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC17A2 →	+0.018	+4.981	<.001	.008	3	2
LARGE_INTESTINE	ACTL7A →	+0.017	+2.560	.004	.009	3	2
KIDNEY	HSF5 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	ZNF728 →	+0.013	+5.000	<.001	.005	3	1
SOFT_TISSUE	SLURP1 →	+0.058	+5.369	<.001	.004	3	1
CNS	LGALS13 →	+0.129	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

SLC17A2 by STOX1 expression — CNS

Explore this box plot interactively →