STON2

Across TCGA patient cohorts, STON2 mutation is significantly associated with the RNA expression of many other genes, with 3,968 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible STON2-associated genes across cancer lineages are NCAPD3, PELO, and SKA1. Each is linked with STON2 in more than 2 cancer types. Because this analysis shows association rather than direction, both STON2-to-partner and partner-to-STON2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPD3 grouped by STON2-low versus STON2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STON2→partner) and Y-score (partner→STON2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPD3 →	+0.479	+2.148	.005	<.001	3	3
SKCM	PELO →	+0.523	+2.555	<.001	<.001	3	3
UCEC	SKA1 →	+0.501	+2.534	.007	<.001	3	3
UCEC	MRPS18C →	+0.309	+2.230	.005	.006	3	3
UCEC	METTL2B →	+0.276	+2.370	.007	.003	3	3
UCEC	NDRG2 →	-1.024	-1.983	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,968 associations by consensus.

NCAPD3 by STON2 expression — UCEC

Explore this box plot interactively →