STON2

Across TCGA cell cohorts, STON2 mutation is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STON2-associated genes across cancer lineages are MYOD1, DBX2, and OR1L3. Each is linked with STON2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STON2-to-partner and partner-to-STON2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by STON2-low versus STON2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STON2→partner) and Y-score (partner→STON2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYOD1 →	+0.014	+3.507	<.001	.004	3	2
LARGE_INTESTINE	DBX2 →	+0.008	+2.977	<.001	.006	3	2
LUNG_NSCLC_LUSC	OR1L3 →	+0.060	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	NLRP8 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PRAMEF8 →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PIWIL3 →	+0.006	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

MYOD1 by STON2 expression — BLOOD_Leukemia

Explore this box plot interactively →