STON1

Across TCGA patient cohorts, STON1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,122 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible STON1-associated genes across cancer lineages are ADAMTS12, IGFBP7-AS1, and STAB2. Each is linked with STON1 in more than 4 cancer types. Because this analysis shows association rather than direction, both STON1-to-partner and partner-to-STON1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, STON1 versus ADAMTS12 in BRCA, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STON1→partner) and Y-score (partner→STON1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADAMTS12 →	+1.336	+0.950	.005	.004	3	5
GBM	IGFBP7-AS1 →	+0.735	+0.708	.002	.001	3	5
LUAD	STAB2 →	+0.725	+0.484	<.001	<.001	3	4
CCRCC	TM6SF2 →	+1.100	+0.682	<.001	.001	3	4
BRCA	ECM2 →	+1.072	+0.897	.008	.007	3	4
BRCA	PKD2 →	+1.144	+0.896	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,122 associations by consensus.

STON1 vs ADAMTS12 — BRCA

Explore this scatter interactively →