STON1

Across TCGA patient cohorts, STON1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STON1-associated genes across cancer lineages are EGFR_pY1068, PCNA, and 14-3-3_epsilon. Each is linked with STON1 in more than 2 cancer types. Because this analysis shows association rather than direction, both STON1-to-partner and partner-to-STON1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by STON1-low versus STON1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STON1→partner) and Y-score (partner→STON1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	EGFR_pY1068 →	+0.685	+3.000	.003	.036	3	3
UCEC	PCNA →	+0.217	+2.247	.001	.001	3	3
SKCM	14-3-3_epsilon →	+0.191	+2.459	<.001	.018	3	2
UCEC	Cyclin-B1 →	+0.838	+2.700	<.001	<.001	3	2
UCEC	FoxM1 →	+0.234	+2.000	.005	<.001	3	2
UCEC	mTOR_pS2448 →	-0.113	-1.980	.019	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

EGFR_pY1068 by STON1 expression — BLCA

Explore this box plot interactively →