STON1

Across TCGA cell cohorts, STON1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible STON1-associated genes across cancer lineages are GJD2, GALNTL5, and PRM2. Each is linked with STON1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STON1-to-partner and partner-to-STON1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJD2 grouped by STON1-low versus STON1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STON1→partner) and Y-score (partner→STON1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GJD2 →	+0.013	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	GALNTL5 →	+0.050	+3.374	<.001	.002	3	1
LUNG_NSCLC_LUAD	PRM2 →	+0.020	+3.944	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR52W1 →	+0.049	+3.906	<.001	.002	3	1
LUNG_NSCLC_LUAD	CSMD1 →	+1.383	+3.548	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.010	+4.302	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GJD2 by STON1 expression — BLOOD_Lymphoma

Explore this box plot interactively →