STOML2

Across TCGA patient cohorts, STOML2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STOML2-associated genes across cancer lineages are eIF4E, MEK1, and Notch1. Each is linked with STOML2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STOML2-to-partner and partner-to-STOML2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by STOML2-low versus STOML2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STOML2→partner) and Y-score (partner→STOML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.244	+3.584	.016	.002	3	1
UCEC	MEK1 →	+0.494	+3.321	.005	.010	3	1
UCEC	Notch1 →	+0.210	+2.459	.001	.020	3	1
UCEC	PCNA →	+0.317	+2.999	.002	.035	3	1
UCEC	STAT3_pY705 →	-0.480	-3.169	<.001	.018	3	1
UCEC	PDCD4 →	-0.788	-2.459	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

eIF4E by STOML2 expression — UCEC

Explore this box plot interactively →