STOML1

Across TCGA patient cohorts, STOML1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STOML1-associated genes across cancer lineages are MEK1, Annexin-1, and VEGFR2. Each is linked with STOML1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STOML1-to-partner and partner-to-STOML1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by STOML1-low versus STOML1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STOML1→partner) and Y-score (partner→STOML1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.393	+3.459	.021	.005	3	1
UCEC	Annexin-1 →	+0.672	+2.584	.006	.011	3	1
UCEC	VEGFR2 →	+0.283	+2.598	.041	.006	3	1
UCEC	Di-Ras3 →	-0.202	-3.308	.003	.009	3	1
UCEC	14-3-3_beta →	-0.144	-2.301	.002	.034	2	1
UCEC	p62 Lck ligand →	+0.387	+3.179	.010	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by STOML1 expression — UCEC

Explore this box plot interactively →