STOM

Across TCGA patient cohorts, STOM mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STOM-associated genes across cancer lineages are PDK1_pS241 and PRAS40_pT246. Each is linked with STOM in more than 1 cancer types. Because this analysis shows association rather than direction, both STOM-to-partner and partner-to-STOM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by STOM-low versus STOM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STOM→partner) and Y-score (partner→STOM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.206	+2.820	.049	.036	3	1
UCEC	PRAS40_pT246 →	+0.247	+2.820	.018	.036	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PDK1_pS241 by STOM expression — UCEC

Explore this box plot interactively →