STOM

Across TCGA cell cohorts, STOM mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STOM-associated genes across cancer lineages are ACER1, EPPIN, and ZAN. Each is linked with STOM in more than 1 cancer types. Because this analysis shows association rather than direction, both STOM-to-partner and partner-to-STOM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by STOM-low versus STOM-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STOM→partner) and Y-score (partner→STOM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.098	+3.823	.001	.006	3	1
BLOOD_Leukemia	EPPIN →	+0.009	+4.507	<.001	.001	3	1
BLOOD_Leukemia	ZAN →	+0.134	+4.133	<.001	.003	3	1
BLOOD_Leukemia	RGR →	+0.021	+4.269	.002	.002	3	1
BLOOD_Leukemia	OR13J1 →	+0.202	+3.774	<.001	.008	3	1
BLOOD_Leukemia	TPRX1 →	+0.010	+4.060	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ACER1 by STOM expression — LARGE_INTESTINE

Explore this box plot interactively →