STMN2

Across TCGA pan-cancer cohorts, STMN2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STMN2 data layer compared with 16 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STMN2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STMN2 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where STMN2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.081	0.768	<.001	48	view →
UCEC	OS	Median	IV	0.133	0.754	<.001	12	view →
SKCM	DFS	Median	III,IV	1.000	0.486	.009	8	view →
KIRC	OS	Median	All	0.178	0.655	.042	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STMN2–HNSC (OS)

Open the HNSC breakdown →