Across TCGA cell cohorts, STK40 mutation is significantly associated with the RNA expression of many other genes, with 307 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STK40-associated genes across cancer lineages are CBY1, BCKDK, and TLE6. Each is linked with STK40 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK40-to-partner and partner-to-STK40 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK40→partner) and Y-score (partner→STK40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBY1 →	+0.618	+3.160	.001	.006	3	1
LARGE_INTESTINE	BCKDK →	+0.548	+3.125	.004	.008	3	1
LARGE_INTESTINE	TLE6 →	+0.988	+3.295	<.001	.003	3	1
LARGE_INTESTINE	ASPN →	+0.037	+3.163	<.001	<.001	3	1
LARGE_INTESTINE	SLC25A11 →	+0.658	+3.169	<.001	.009	3	1
LARGE_INTESTINE	ZNF330 →	+0.484	+3.502	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 307 associations by consensus.

Exploration

STK40 survival (RNA) · tumor vs normal (RNA) · all STK40 data types