STK4

Across TCGA pan-cancer cohorts, STK4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STK4 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher STK4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STK4 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

OV, SCLC, and LIHC are the cancer types where STK4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.285	0.843	<.001	36	view →
SCLC	OS	Median	All	0.082	0.822	<.001	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
SKCM	DFS	Median	All	0.997	0.730	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STK4–OV (OS)

Open the OV breakdown →