STK4

Across TCGA patient cohorts, STK4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK4-associated genes across cancer lineages are PDCD4, eIF4G, and ERK2. Each is linked with STK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK4-to-partner and partner-to-STK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by STK4-low versus STK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK4→partner) and Y-score (partner→STK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.597	-2.105	.001	.017	3	2
UCEC	eIF4G →	+0.346	+2.502	.004	.002	3	1
UCEC	ERK2 →	+0.244	+2.321	.001	.005	3	1
UCEC	INPP4B →	-0.259	-3.169	.041	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-3.156	.002	<.001	3	1
UCEC	JNK2 →	+0.203	+2.000	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PDCD4 by STK4 expression — UCEC

Explore this box plot interactively →