STK38

Across TCGA pan-cancer cohorts, STK38 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated STK38 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STK38 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated STK38 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where STK38 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.986	0.885	.005	35	view →
PDAC	OS	Quartile	All	0.497	0.995	<.001	28	view →
LSCC	OS	Tertile	All	0.923	0.689	.003	13	view →
GBM	DFS	Median	All	0.662	0.770	.045	3	view →
CCRCC	OS	Median	II,III,IV	0.829	0.635	.028	1	view →
LUAD	OS	Median	All	0.940	0.704	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

STK38–HNSC (DFS)

Open the HNSC breakdown →