STK38

Across TCGA patient cohorts, STK38 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK38-associated genes across cancer lineages are Gab2, ATM, and 14-3-3_beta. Each is linked with STK38 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK38-to-partner and partner-to-STK38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by STK38-low versus STK38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK38→partner) and Y-score (partner→STK38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.385	+1.584	.006	.036	3	2
UCEC	ATM →	-0.492	-2.000	.005	.010	3	2
UCEC	14-3-3_beta →	-0.115	-2.088	.003	.016	3	1
UCEC	eEF2 →	+0.313	+1.584	.026	.036	3	1
UCEC	A-Raf_pS299 →	-0.144	-2.115	.002	.017	3	1
UCEC	Ku80 →	+0.192	+1.598	.038	.022	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Gab2 by STK38 expression — UCEC

Explore this box plot interactively →