STK38

Across TCGA cell cohorts, STK38 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STK38-associated genes across cancer lineages are TLX3, USP17L7, and DCANP1. Each is linked with STK38 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK38-to-partner and partner-to-STK38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLX3 grouped by STK38-low versus STK38-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK38→partner) and Y-score (partner→STK38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TLX3 →	+0.478	+3.845	<.001	.003	3	1
LARGE_INTESTINE	USP17L7 →	+0.080	+4.013	<.001	.001	3	1
LARGE_INTESTINE	DCANP1 →	+0.008	+3.347	.004	.005	3	1
LARGE_INTESTINE	CPO →	+0.180	+3.514	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TLX3 by STK38 expression — LARGE_INTESTINE

Explore this box plot interactively →