STK36

Across TCGA patient cohorts, STK36 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK36-associated genes across cancer lineages are Src, PDCD4, and eEF2. Each is linked with STK36 in more than 2 cancer types. Because this analysis shows association rather than direction, both STK36-to-partner and partner-to-STK36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src grouped by STK36-low versus STK36-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK36→partner) and Y-score (partner→STK36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Src →	-0.200	-2.000	.025	.009	3	3
UCEC	PDCD4 →	-0.718	-3.169	<.001	<.001	3	3
SKCM	eEF2 →	+0.341	+2.186	.008	.032	3	2
UCEC	JNK_pT183_Y185 →	-0.123	-1.861	.029	.002	3	2
SKCM	p90 RSK →	+0.237	+1.584	.003	.035	3	2
SKCM	PCNA →	+0.293	+2.502	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Src by STK36 expression — SKCM

Explore this box plot interactively →