STK35

Across TCGA pan-cancer cohorts, STK35 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated STK35 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher STK35 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated STK35 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

UCEC and BLCA are the cancer types where STK35 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
BLCA	DFS	Median	III,IV	0.511	0.315	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

STK35–UCEC (OS)

Open the UCEC breakdown →