STK35

Across TCGA patient cohorts, STK35 mutation is significantly associated with the RNA expression of many other genes, with 599 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK35-associated genes across cancer lineages are LINC01789, RNU6-147P, and MTATP6P21. Each is linked with STK35 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK35-to-partner and partner-to-STK35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01789 grouped by STK35-low versus STK35-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK35→partner) and Y-score (partner→STK35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01789 →	+0.841	+5.800	<.001	.003	3	2
UCEC	RNU6-147P →	+0.207	+2.873	.001	<.001	3	2
UCEC	MTATP6P21 →	+0.291	+1.967	<.001	.005	3	2
UCEC	OR7E101P →	+0.263	+1.733	<.001	.007	3	2
LUSC	IGHVII-15-1 →	+0.175	+6.309	.008	.001	3	2
BRCA	MIR3118-3 →	+0.371	+7.471	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 599 associations by consensus.

LINC01789 by STK35 expression — BRCA

Explore this box plot interactively →