STK35

Across TCGA patient cohorts, STK35 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK35-associated genes across cancer lineages are JNK_pT183_Y185, A-Raf_pS299, and ERK2. Each is linked with STK35 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK35-to-partner and partner-to-STK35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by STK35-low versus STK35-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK35→partner) and Y-score (partner→STK35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.195	-1.986	.010	.032	3	2
UCEC	A-Raf_pS299 →	-0.186	-3.321	<.001	.010	3	1
UCEC	ERK2 →	+0.250	+2.000	.004	.032	3	1
UCEC	FOXO3a_pS318_S321 →	-0.128	-2.449	.022	.019	3	1
UCEC	Ku80 →	+0.378	+3.820	<.001	<.001	3	1
UCEC	MEK1 →	+0.565	+2.000	<.001	.030	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

JNK_pT183_Y185 by STK35 expression — UCEC

Explore this box plot interactively →