STK35

Across TCGA cell cohorts, STK35 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,011 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STK35-associated GO terms across cancer lineages are Negative regulation of meiotic cell cycle phase transition, Regulation of protein localization to endoplasmic reticulum, and Positive regulation of protein localization to endoplasmic reticulum. Each is linked with STK35 in more than 18 cancer types. Because this analysis shows association rather than direction, both STK35-to-partner and partner-to-STK35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of meiotic cell cycle phase transition grouped by STK35-low versus STK35-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STK35→partner) and Y-score (partner→STK35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of meiotic cell cycle phase transition →	+0.164	+0.698	<.001	<.001	3	19
OESOPHAGUS	Regulation of protein localization to endoplasmic reticulum →	+0.150	+1.001	<.001	<.001	3	18
OESOPHAGUS	Positive regulation of protein localization to endoplasmic reticulum →	+0.137	+0.988	<.001	<.001	3	17
BLOOD_Lymphoma	Sex-chromosome dosage compensation →	+0.112	+0.867	<.001	<.001	3	14
SOFT_TISSUE	Nucleic acid transport →	+0.114	+0.782	<.001	<.001	3	13
SOFT_TISSUE	RNA transport →	+0.114	+0.782	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,011 associations by consensus.

Negative regulation of meiotic cell cycle phase transition by STK35 expression — LUNG_SCLC

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