STK35

Across TCGA cell cohorts, STK35 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STK35-associated genes across cancer lineages are MAGEB4, DAZ4, and CCDC195. Each is linked with STK35 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK35-to-partner and partner-to-STK35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by STK35-low versus STK35-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK35→partner) and Y-score (partner→STK35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	DAZ4 →	+0.123	+3.240	.004	.004	3	1
LARGE_INTESTINE	CCDC195 →	+0.039	+2.882	<.001	.005	3	1
LARGE_INTESTINE	CHRNA2 →	+0.071	+2.716	<.001	.009	2	1
LARGE_INTESTINE	C1QTNF7 →	+0.060	+2.938	.007	.006	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MAGEB4 by STK35 expression — LARGE_INTESTINE

Explore this box plot interactively →