STK33

Across TCGA patient cohorts, STK33 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK33-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and ATM. Each is linked with STK33 in more than 2 cancer types. Because this analysis shows association rather than direction, both STK33-to-partner and partner-to-STK33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by STK33-low versus STK33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK33→partner) and Y-score (partner→STK33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.445	+1.827	.037	.015	3	3
UCEC	FoxM1 →	+0.223	+2.321	.016	.001	3	2
UCEC	ATM →	-0.676	-2.321	<.001	.001	3	2
UCEC	Caspase-8 →	-0.260	-2.973	.004	<.001	3	2
UCEC	Cyclin-B1 →	+0.826	+2.807	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.240	-1.925	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by STK33 expression — UCEC

Explore this box plot interactively →