STK33

Across TCGA cell cohorts, STK33 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible STK33-associated genes across cancer lineages are SIRPD, R3HDML, and OR13H1. Each is linked with STK33 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK33-to-partner and partner-to-STK33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIRPD grouped by STK33-low versus STK33-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK33→partner) and Y-score (partner→STK33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIRPD →	+0.012	+3.240	<.001	.004	3	2
PANCREAS	R3HDML →	+1.095	+4.237	<.001	.006	3	1
PANCREAS	OR13H1 →	+0.041	+4.011	.008	.009	3	1
PANCREAS	TSPY4 →	+0.037	+4.614	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR6M1 →	+0.040	+4.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SKOR2 →	+0.019	+3.947	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SIRPD by STK33 expression — LARGE_INTESTINE

Explore this box plot interactively →