STK26

Across TCGA patient cohorts, STK26 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK26-associated genes across cancer lineages are eIF4E, p38-MAPK_pT180_Y182, and Stathmin. Each is linked with STK26 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK26-to-partner and partner-to-STK26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by STK26-low versus STK26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK26→partner) and Y-score (partner→STK26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.154	+1.502	.047	.030	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.460	-2.222	.005	.010	3	2
UCEC	Stathmin →	+0.099	+1.502	.049	.030	3	2
UCEC	VHL →	-0.891	-1.502	<.001	.030	3	2
UCEC	c-Met_pY1235 →	+0.055	+1.710	.042	.025	3	2
UCEC	14-3-3_beta →	-0.102	-2.234	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by STK26 expression — UCEC

Explore this box plot interactively →