STK24

Across TCGA pan-cancer cohorts, STK24 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated STK24 data layer compared with 19 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher STK24 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated STK24 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and ESCA are the cancer types where STK24 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.128	0.710	.001	36	view →
UCEC	DFS	Median	All	0.958	0.611	.007	34	view →
ESCA	OS	Median	All	0.095	0.701	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

STK24–HNSC (DFS)

Open the HNSC breakdown →