STK24

Across TCGA patient cohorts, STK24 mutation is significantly associated with the RNA expression of many other genes, with 3,113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK24-associated genes across cancer lineages are PGAP2, UEVLD, and BAG3. Each is linked with STK24 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK24-to-partner and partner-to-STK24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAP2 grouped by STK24-low versus STK24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK24→partner) and Y-score (partner→STK24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAP2 →	+0.350	+2.010	.002	<.001	3	2
UCEC	UEVLD →	+0.355	+2.147	.008	.009	3	2
UCEC	BAG3 →	+0.711	+2.700	<.001	<.001	3	2
UCEC	BSDC1 →	+0.316	+2.264	.007	.001	3	2
UCEC	HSPA4L →	+0.755	+1.737	<.001	.002	3	2
UCEC	PDSS2 →	+0.440	+2.247	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,113 associations by consensus.

PGAP2 by STK24 expression — UCEC

Explore this box plot interactively →