STK16

Across TCGA patient cohorts, STK16 mutation is significantly associated with the RNA expression of many other genes, with 1,842 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK16-associated genes across cancer lineages are UGT2B10, SNORD53, and NDUFB5P2. Each is linked with STK16 in more than 1 cancer types. Because this analysis shows association rather than direction, both STK16-to-partner and partner-to-STK16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UGT2B10 grouped by STK16-low versus STK16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK16→partner) and Y-score (partner→STK16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UGT2B10 →	+0.119	+1.719	.001	.008	3	2
UCEC	SNORD53 →	+0.453	+2.148	.003	<.001	3	2
SKCM	NDUFB5P2 →	+0.087	+4.744	<.001	.001	3	1
SKCM	RPS17P17 →	+0.093	+4.495	.007	.007	3	1
UCEC	PTPRJ →	+0.688	+3.721	<.001	<.001	3	1
UCEC	COX15 →	+0.387	+3.008	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,842 associations by consensus.

UGT2B10 by STK16 expression — UCEC

Explore this box plot interactively →