STK11

Across TCGA pan-cancer cohorts, STK11 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of STK11’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where STK11 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types STK11 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where STK11 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STK11 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	II,III,IV	−0.268	<.001	9	view →
LUAD	Male	All	−0.366	<.001	8	view →
HNSC	Male	All	−0.295	<.001	6	view →
CCRCC	All	II,III,IV	−0.199	.007	6	view →
PDAC	Male	IV	−0.585	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

STK11–LSCC

Open the LSCC breakdown →