STIP1

Across TCGA patient cohorts, STIP1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STIP1-associated genes across cancer lineages are MIG-6, Caspase-7-cleavedD198, and c-Met_pY1235. Each is linked with STIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both STIP1-to-partner and partner-to-STIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by STIP1-low versus STIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STIP1→partner) and Y-score (partner→STIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.113	+1.515	.001	.018	3	3
UCEC	Caspase-7-cleavedD198 →	+0.954	+2.736	<.001	<.001	3	3
UCEC	c-Met_pY1235 →	+0.071	+1.700	.009	.040	3	3
UCEC	eEF2 →	+0.322	+3.459	.014	.005	3	2
UCEC	MSH6 →	-0.328	-2.459	.006	.018	3	2
UCEC	PCNA →	+0.235	+2.700	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MIG-6 by STIP1 expression — UCEC

Explore this box plot interactively →