Across TCGA cell cohorts, STING1 mutation is significantly associated with the RNA expression of many other genes, with 142 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible STING1-associated genes across cancer lineages are DCAF16, ACER1, and TBC1D28. Each is linked with STING1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STING1-to-partner and partner-to-STING1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STING1→partner) and Y-score (partner→STING1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DCAF16 →	+0.735	+3.115	.001	.009	3	2
BLOOD_Leukemia	ACER1 →	+0.257	+3.894	<.001	.001	3	2
BLOOD_Leukemia	TBC1D28 →	+0.072	+2.604	<.001	.006	3	2
LARGE_INTESTINE	SIGLEC1 →	+0.128	+3.679	.001	.005	3	1
LARGE_INTESTINE	AMELY →	+0.025	+3.700	<.001	.009	3	1
BLOOD_Leukemia	VSX1 →	+0.278	+3.306	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 142 associations by consensus.

Exploration

STING1 survival (RNA) · tumor vs normal (RNA) · all STING1 data types