Across TCGA patient cohorts, STIMATE mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STIMATE-associated genes across cancer lineages are EGFR_pY1068, ERK2, and GSK-3_pS9. Each is linked with STIMATE in more than 1 cancer types. Because this analysis shows association rather than direction, both STIMATE-to-partner and partner-to-STIMATE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STIMATE→partner) and Y-score (partner→STIMATE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.246	-2.584	.035	.011	3	1
UCEC	ERK2 →	+0.242	+2.584	.006	.010	3	1
UCEC	GSK-3_pS9 →	-0.527	-3.459	.005	.005	3	1
UCEC	MAPK_pT202_Y204 →	-0.507	-3.321	.020	.010	3	1
UCEC	MEK1 →	+0.512	+3.321	.002	.010	3	1
UCEC	Notch1 →	+0.211	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

STIMATE survival (RNA) · tumor vs normal (RNA) · all STIMATE data types