STIM2

Across TCGA patient cohorts, STIM2 mutation is significantly associated with the RNA expression of many other genes, with 3,988 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STIM2-associated genes across cancer lineages are POLE2, OIP5, and ACYP1. Each is linked with STIM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both STIM2-to-partner and partner-to-STIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by STIM2-low versus STIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STIM2→partner) and Y-score (partner→STIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLE2 →	+0.561	+1.743	<.001	<.001	3	3
UCEC	OIP5 →	+0.871	+1.743	<.001	<.001	3	3
UCEC	ACYP1 →	+0.440	+2.384	<.001	<.001	3	3
UCEC	STIL →	+0.516	+2.758	<.001	<.001	3	3
UCEC	CKS2 →	+0.708	+2.362	<.001	<.001	3	3
SKCM	KNSTRN →	+0.665	+3.198	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,988 associations by consensus.

POLE2 by STIM2 expression — UCEC

Explore this box plot interactively →