STIM2

Across TCGA patient cohorts, STIM2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STIM2-associated genes across cancer lineages are eIF4E, p62 Lck ligand, and PDCD4. Each is linked with STIM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both STIM2-to-partner and partner-to-STIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by STIM2-low versus STIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STIM2→partner) and Y-score (partner→STIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.201	+2.392	.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.282	+1.672	.004	.006	3	2
UCEC	PDCD4 →	-0.302	-1.700	.033	.040	3	2
UCEC	ATM →	-0.411	-2.571	.002	<.001	3	2
UCEC	c-Kit →	-0.147	-1.321	.037	.012	3	2
UCEC	Cyclin-B1 →	+0.479	+1.321	.004	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eIF4E by STIM2 expression — UCEC

Explore this box plot interactively →