STIM2

Across TCGA cell cohorts, STIM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,067 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible STIM2-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Negative regulation of cell cycle process, and Regulation of store-operated calcium channel activity. Each is linked with STIM2 in more than 13 cancer types. Because this analysis shows association rather than direction, both STIM2-to-partner and partner-to-STIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by STIM2-low versus STIM2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STIM2→partner) and Y-score (partner→STIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.098	+1.420	<.001	<.001	3	14
LARGE_INTESTINE	Negative regulation of cell cycle process →	+0.068	+1.091	<.001	<.001	3	14
LIVER	Regulation of store-operated calcium channel activity →	+0.135	+1.222	<.001	<.001	3	13
BREAST	Negative regulation of mRNA splicing, via spliceosome →	+0.102	+1.143	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription elongation →	+0.061	+0.877	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.048	+0.983	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,067 associations by consensus.

Regulation of mRNA splicing, via spliceosome by STIM2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →