STEAP3

Across TCGA pan-cancer cohorts, STEAP3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated STEAP3 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher STEAP3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated STEAP3 expression acts as an unfavorable survival marker.

COAD, UCEC, and STAD are the cancer types where STEAP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.222	0.695	<.001	15	view →
UCEC	OS	Median	IV	0.259	0.770	<.001	12	view →
STAD	OS	Median	III,IV	0.003	0.630	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

STEAP3–COAD (DFS)

Open the COAD breakdown →