STEAP3

Across TCGA pan-cancer cohorts, STEAP3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated STEAP3 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher STEAP3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated STEAP3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where STEAP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.318	0.818	<.001	102	view →
HNSC	DFS	Median	II,III,IV	0.508	0.800	<.001	54	view →
UCEC	DFS	Tertile	All	0.947	0.765	.013	4	view →
LSCC	DFS	Median	All	0.831	0.495	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

STEAP3–CCRCC (DFS)

Open the CCRCC breakdown →