STEAP3

Across TCGA patient cohorts, STEAP3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STEAP3-associated genes across cancer lineages are eIF4E, Annexin-1, and Cyclin-B1. Each is linked with STEAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both STEAP3-to-partner and partner-to-STEAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by STEAP3-low versus STEAP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP3→partner) and Y-score (partner→STEAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.159	+2.169	.019	.003	3	3
UCEC	Annexin-1 →	+0.399	+2.522	.019	<.001	3	2
UCEC	Cyclin-B1 →	+0.446	+2.222	.014	.010	3	2
UCEC	ERK2 →	+0.164	+1.765	.008	.013	3	1
UCEC	GAPDH →	+0.557	+2.000	.001	<.001	3	1
UCEC	Heregulin →	-0.105	-1.765	.008	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eIF4E by STEAP3 expression — UCEC

Explore this box plot interactively →