STEAP3

Across TCGA cell cohorts, STEAP3 mutation is significantly associated with the mutation status of many other genes, with 2,851 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STEAP3-associated genes across cancer lineages are LRIG1, RXRA, and PCDHB11. Each is linked with STEAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both STEAP3-to-partner and partner-to-STEAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIG1 grouped by STEAP3-low versus STEAP3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STEAP3→partner) and Y-score (partner→STEAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LRIG1 →	+4.614	+5.584	<.001	<.001	1	3
CNS	RXRA →	+4.614	+4.614	.006	.006	1	3
CNS	PCDHB11 →	+5.199	+5.862	<.001	<.001	1	3
LARGE_INTESTINE	PLXNA2 →	+1.719	+3.807	.001	.001	1	3
BLOOD_Lymphoma	SEMA3G →	+6.014	+6.014	.001	.001	1	3
BLOOD_Leukemia	SNX9 →	+4.736	+5.560	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,851 associations by consensus.

LRIG1 by STEAP3 expression — CNS

Explore this box plot interactively →